Union Rate and Complications in Spine Fusion with Recombinant Human Bone Morphogenetic Protein-7: Systematic Review and Meta-Analysis
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چکیده
منابع مشابه
Union Rate and Complications in Spine Fusion with Recombinant Human Bone Morphogenetic Protein-7: Systematic Review and Meta-Analysis
Study Design Systematic review and meta-analysis. Objective The objective of this meta-analysis was to evaluate the current best evidence to assess effectiveness and safety of recombinant human bone morphogenetic protein-7 (rhBMP-7) as a biological stimulant in spine fusion. Methods Studies were included if they reported on outcomes after spine fusion with rhBMP-7. The data was synthesized usin...
متن کاملEffectiveness and harms of recombinant human bone morphogenetic protein-2 in spine fusion: a systematic review and meta-analysis.
BACKGROUND Recombinant human bone morphogenetic protein-2 (rhBMP-2) is used as a bone graft substitute in spinal fusion, which unites (fuses) bones in the spine. The accuracy and completeness of journal publications of industry-sponsored trials on the effectiveness and harms of rhBMP-2 has been called into question. PURPOSE To independently assess the effectiveness and harms of rhBMP-2 in spi...
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STUDY DESIGN Retrospective cohort study using the Washington State Comprehensive Hospital Abstract Reporting System, the Washington State Cancer Registry, and Washington State death certificates. OBJECTIVE To study the possible association between recombinant human bone morphogenetic protein (rhBMP) and cancer risk. SUMMARY OF BACKGROUND DATA The use of rhBMP in spine fusion surgery remains...
متن کاملRecombinant human Bone Morphogenetic Protein-2 (rhBMP-2) in posterolateral lumbar spine fusion: complications in the elderly
STUDY DESIGN Retrospective cohort study of 1430 patients undergoing lumbar spinal fusion from 2002 - 2009. OBJECTIVE The goal of this study was to compare and evaluate the number of complications requiring reoperation in elderly versus younger patients. SUMMARY OF BACKGROUND DATA rhBMP-2 has been utilized off label for instrumented lumbar posterolateral fusions for many years. Many series h...
متن کاملComplications Associated With Bone Morphogenetic Protein in the Lumbar Spine.
Complications associated with the use of recombinant human bone morphogenetic protein in the lumbar spine include retrograde ejaculation, ectopic bone formation, vertebral osteolysis and subsidence, postoperative radiculitis, and hematoma and seroma. These complications are controversial and remain widely debated. This article discusses the reported complications and possible implications for t...
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ژورنال
عنوان ژورنال: Global Spine Journal
سال: 2015
ISSN: 2192-5682,2192-5690
DOI: 10.1055/s-0035-1557143